Share to Facebook Share to Twitter Share to LinkedIn Pinterest Email

Einstein Image

Einstein Image

A bundle of hypothalamic neurons called the arcuate nucleus (ARC) helps control food intake and metabolism. The ARC’s pro-opiomelanocortin (POMC) neurons are particularly important; their POMC gene spawns peptides that powerfully inhibit food intake.

Streamson Chua, M.D., Ph.D., a professor of medicine and in the Dominick P. Purpura Department of Neuroscience, studies POMC and other genes that regulate body weight and fat content. As shown in this image of a mouse hypothalamus, the ARC is adjacent to the pyramid-shaped third ventricle, a fluid-filled space in the brain. POMC neurons stained green/yellow are actively expressing the POMC gene; neurons stained red express an enzyme called Cre recombinase, which tags any cells that have ever expressed POMC.

The image shows that many neurons express POMC during growth and development, but only a fraction develop into adult POMC-expressing neurons. A blue stain called DAPI, which binds to cell nuclei, colors other cells in the region. This image was made by Niloy Iqbal, an M.D./Ph.D. student co-mentored by Dr. Chua and Liang Zhu, M.D., Ph.D., a professor of developmental and molecular biology, of ophthalmology and visual sciences, and of medicine.   

Share to Facebook Share to Twitter Share to LinkedIn Share to Pinterest Email

More From Einstein

Class of 2025 Attends White Coat Ceremony
Rising Social Media Star Heather Irobunda
Doctor’s Commitment to 9/11 First Responders
How to Be a Resilient Scientist
Einstein Hosts National Postdoc Conference
Celebrating the Ph.D. Convocation
Striving for Success Against Heart Failure
Lecture Series Highlights Global Health Issues
Medical Student Leads Rescue
Dennis Shields Prizes Awarded


Campus News
Research Notes
Motivations: Donors & Alumni


Share to Facebook Share to Twitter Share to LinkedIn Email

Past Issues

Download Magazine