Research Notes

Understanding Virus-Host Interactions

Understanding Virus-Host Interactions

Some genes code for transfer RNA (tRNA) molecules, which are crucially important in synthesizing proteins based on instructions in the genetic code. Viruses are thought to be under selective pressure to maintain compact genomes, causing them to depend on the host cell’s translational machinery to reproduce themselves. However, some viruses encode abundant transfer RNA (tRNA) genes—presumably for a reason.

In a study published in June 2021 in Cell Systems, Libusha Kelly, Ph.D., and colleagues examined whether carrying a large number of tRNA genes—18 in total—confers a survival advantage to a virus that infects marine Vibrio bacteria. The researchers found that viral infection causes bacterial DNA and RNA (including tRNA) to degrade and that tRNA levels reach a minimum 15 minutes into infection, while newly synthesized viral particles aren’t released until 30 minutes into infection.

In addition, all 18 of the virus’s tRNA genes are expressed during infection. The findings suggest that viruses possess so many tRNA genes because they must carry out translation and protein synthesis even as their hosts’ DNA and RNA are degraded during infection.

Dr. Kelly is an associate professor of systems & computational biology and of microbiology & immunology.

More From Einstein

Preparing New Grads for Hospital Roles
Einstein Celebrates 65th Commencement
Class of 2027 Receives White Coats
Mentoring in Medicine Paves Way for Success
Biomedical Sciences Leadership Program Begins
Einstein, Lehman Launch M.S. Program
2023 National Diversity Award
Health Equity Scholarship Honors Nilda Soto
Longevity Gene Project Awarded $13.6M


Campus News
Research Notes
Motivations: Donors & Alumni
More From This Issue

Past Issues

Download Magazine



  • This field is for validation purposes and should be left unchanged.